Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

Y Tan, Z Zhang, C Zheng, KA Wintergerst… - Nature Reviews …, 2020 - nature.com
The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …

CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

One week of bed rest leads to substantial muscle atrophy and induces whole-body insulin resistance in the absence of skeletal muscle lipid accumulation

ML Dirks, BT Wall, B Van De Valk, TM Holloway… - Diabetes, 2016 - Am Diabetes Assoc
Short (< 10 days) periods of muscle disuse, often necessary for recovery from illness or
injury, lead to various negative health consequences. The current study investigated …

Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization

JFC Glatz, JJFP Luiken - Journal of lipid research, 2018 - ASBMB
The widely expressed transmembrane glycoprotein, cluster of differentiation 36 (CD36), a
scavenger receptor class B protein (SR-B2), serves many functions in lipid metabolism and …

Muscle lipid metabolism: role of lipid droplets and perilipins

PE Morales, JL Bucarey… - Journal of diabetes …, 2017 - Wiley Online Library
Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our
organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) …

From fat to FAT (CD36/SR-B2): Understanding the regulation of cellular fatty acid uptake

JFC Glatz, JJFP Luiken - Biochimie, 2017 - Elsevier
The molecular mechanisms underlying the cellular uptake of long-chain fatty acids and the
regulation of this process have been elucidated in appreciable detail in the last decades …

CD36 (SR-B2) as master regulator of cellular fatty acid homeostasis

JFC Glatz, M Nabben, JJFP Luiken - Current opinion in lipidology, 2022 - journals.lww.com
The emerging central role of CD36 in cellular lipid homeostasis and recently obtained
molecular insight in the interplay among metabolic substrates indicate the applicability of …

The impact of bed rest on human skeletal muscle metabolism

M Eggelbusch, BT Charlton, A Bosutti, B Ganse… - Cell Reports …, 2024 - cell.com
Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal
and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we …

The multifunctionality of CD36 in diabetes mellitus and its complications—update in pathogenesis, treatment and monitoring

K Puchałowicz, ME Rać - Cells, 2020 - mdpi.com
CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune
response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes …

CD36 signal transduction in metabolic diseases: novel insights and therapeutic targeting

U Karunakaran, S Elumalai, JS Moon, KC Won - Cells, 2021 - mdpi.com
The cluster of differentiation 36 (CD36) is a scavenger receptor present on various types of
cells and has multiple biological functions that may be important in inflammation and in the …