Current clinical applications of diffusion-tensor imaging in neurological disorders

WS Tae, BJ Ham, SB Pyun… - Journal of Clinical …, 2018 - synapse.koreamed.org
Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the
structure of white matter. The signal contrast in DTI is generated by differences in the …

Leveraging visual outcome measures to advance therapy development in neuroimmunologic disorders

JS Graves, FC Oertel, A Van der Walt… - Neurology …, 2021 - AAN Enterprises
The visual system offers unparalleled precision in the assessment of neuroaxonal damage.
With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent …

Visual evoked potentials as a biomarker in multiple sclerosis and associated optic neuritis

L Leocani, S Guerrieri, G Comi - Journal of Neuro-Ophthalmology, 2018 - journals.lww.com
Abstract From the Section Editor: The next two installments in the JNO “Disease of the Year:
Multiple Sclerosis” series focus on lessons that can be learned form the afferent visual …

[HTML][HTML] Fibre-specific white matter changes in multiple sclerosis patients with optic neuritis

S Gajamange, D Raffelt, T Dhollander, E Lui… - NeuroImage: Clinical, 2018 - Elsevier
Long term irreversible disability in multiple sclerosis (MS) is thought to be primarily driven by
axonal degeneration. Axonal degeneration leads to degenerative atrophy, therefore early …

Novel uses of retinal imaging with optical coherence tomography in multiple sclerosis

FC Oertel, HG Zimmermann, AU Brandt… - Expert Review of …, 2019 - Taylor & Francis
ABSTRACT Introduction: Multiple Sclerosis (MS) is the most common chronic autoimmune
neuroinflammatory condition in young adults. It is often accompanied by optic neuritis (ON) …

Axonal degeneration in multiple sclerosis: can we predict and prevent permanent disability?

JY Lee, K Taghian, S Petratos - Acta neuropathologica communications, 2014 - Springer
Axonal degeneration is a major determinant of permanent neurological impairment during
multiple sclerosis (MS). Due to the variable course of clinical disease and the heterogeneity …

Multifocal visual evoked potentials in optic neuritis and multiple sclerosis: a review

G Pihl-Jensen, MF Schmidt, JL Frederiksen - Clinical Neurophysiology, 2017 - Elsevier
Multifocal visual evoked potential (mf-VEP) represents a new approach to the classical full
field (ff-) VEP with separate responses from up to 60 sectors of the visual field. A thorough …

Sequential phases of RGC axonal and somatic injury in EAE mice examined using DTI and OCT

C Nishioka, HF Liang, B Barsamian, SW Sun - Multiple sclerosis and …, 2019 - Elsevier
Background Clinical imaging modalities including optical coherence tomography (OCT) and
diffusion tensor imaging (DTI) are vital in Multiple Sclerosis (MS), but their relationships …

Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model

C Nishioka, HF Liang, B Barsamian, SW Sun - Neuroimage, 2019 - Elsevier
White matter abnormalities, revealed by Diffusion Tensor Imaging (DTI), are observed in
patients with Alzheimer's Disease (AD), representing neural network deficits that underlie …

Diffuse and focal corticospinal tract disease and its impact on patient disability in multiple sclerosis

F Tovar‐Moll, IE Evangelou, AW Chiu… - Journal of …, 2015 - Wiley Online Library
ABSTRACT BACKGROUND AND PURPOSE We investigated the impact of focal and diffuse
corticospinal tracts damage on sensory‐motor disability in multiple sclerosis (MS) patients …