Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …

Statins, which are competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A
reductase, reduce cholesterol blood levels and the risk of developing cardiovascular …

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are
needed. Altered metabolism is a cancer vulnerability, and several metabolic pathways have …

АВ—атриовентрикулярный (ая) АГ—артериальная гипертензия АД—артериальное
давление АТ—артериальный тромбоз АТО—атеротромботические осложнения АТФ …

Statins have been shown to inhibit cell proliferation in vitro and tumor growth in animal
models. Various studies have also shown a decreased cancer-specific mortality rate in …

Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination.
Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight …

Statins are among the most commonly prescribed drugs, and around every fourth person
above the age of 40 is on statin medication. Therefore, it is of utmost clinical importance to …

Pancreatic cancer (PaCa) is one of the deadliest cancers known and its incidence is
increasing in the developed countries. Because of the lack of biomarkers that allow early …

Prior studies demonstrated that the irreversible ERBB1/2/4 inhibitor neratinib caused plasma
membrane-associated mutant K-RAS to localize in intracellular vesicles, concomitant with its …

Cancer is a disease with a significant global burden in terms of premature mortality, loss of
productivity, healthcare expenditures, and impact on mental health. Recent decades have …