Background Trials examining the benefit of thrombectomy in anterior circulation proximal
large vessel occlusion stroke have enrolled patients considered to have salvageable brain …

MicroRNAs (miRNAs) are small regulatory molecules post-transcriptionally suppressing
mRNA activity. Many miRNAs in various organisms have been cloned but many unknown …

Background The role of endovascular therapy for acute stroke with a large infarction has not
been extensively studied in differing populations. Methods We conducted a multicenter …

Background Data from trials investigating the effects and risks of endovascular
thrombectomy for the treatment of stroke due to basilar-artery occlusion are limited. Methods …

Background The value of administering intravenous alteplase before endovascular
treatment (EVT) for acute ischemic stroke has not been studied extensively, particularly in …

Background Recent evidence suggests a beneficial effect of endovascular thrombectomy in
acute ischaemic stroke with large infarct; however, previous trials have relied on multimodal …

Background The optimum systolic blood pressure after endovascular thrombectomy for
acute ischaemic stroke is uncertain. We aimed to compare the safety and efficacy of blood …

Background Endovascular treatment for anterior circulation ischaemic stroke is effective and
safe within a 6 h window. MR CLEAN-LATE aimed to assess efficacy and safety of …

Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …

Summary Background Asundexian (Bayer AG, Leverkusen, Germany), an oral small
molecule factor XIa (FXIa) inhibitor, might prevent thrombosis without increasing bleeding …