In view of their exceptional approach, excellent inherent biocompatibility and
biodegradability properties, and interaction with the local extracellular matrix, protein-based …

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons
worldwide. Despite the variety of surgical techniques, current clinical strategies for bone …

Despite recent advances in bone adhesives applied for full median sternotomy, the
regeneration of bone defects has remained challenging since the healing process is …

3D printed/bioprinted tissue constructs are utilized for the regeneration of damaged tissues
and as in vitro models. Most of the fabricated 3D constructs fail to undergo functional …

Decellularized extracellular matrix (dECM)‐based hydrogels are widely applied to additive
biomanufacturing strategies for relevant applications. The extracellular matrix components …

It has been observed that bone fractures carry a risk of high mortality and morbidity. The
deployment of a proper bone healing method is essential to achieve the desired success …

Various perfusion bioreactor systems have been designed to improve cell culture with three-
dimensional porous scaffolds, and there is some evidence that fluid force improves the …

Integrin is a widely distributed adhesion molecule on cell membrane surface, which plays a
role in transferring mechanical properties signals of the extracellular matrix into cells during …

The fate and behavior of bone marrow mesenchymal stem/stromal cells (BM-MSC) is
bidirectionally influenced by their microenvironment, the stem cell niche, where a magnitude …

Osteocytes perceive and process mechanical stimuli in the lacuno-canalicular network in
bone. As a result, they secrete signaling molecules that mediate bone formation and …