Gliomas are the most common primary brain tumors in adults. Despite the fact that they are
relatively rare, they cause significant morbidity and mortality. High-grade gliomas or …

High-grade gliomas are rapidly progressing tumors of the central nervous system (CNS) with
a very poor prognosis despite extensive resection combined with radiation and/or …

Mutations in codon 132 of isocitrate dehydrogenase (IDH) 1 are frequent in diffuse glioma,
acute myeloid leukemia, chondrosarcoma and intrahepatic cholangiocarcinoma. These …

Treatment failure for the lethal brain tumor glioblastoma (GBM) is attributed to intratumoral
heterogeneity and tumor evolution. We utilized 3D neuronavigation during surgical resection …

Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Despite
the combination of novel therapeutical approaches, it remains a deadly malignancy with an …

Abstract Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic
mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine …

Background Glioma is one of the highly fatal primary tumors in the central nervous system.
As a major component of tumor microenvironment (TME), immune cell has been proved to …

Hypothalamic tanycytes in median eminence (ME) are emerging as a crucial cell population
that regulates endocrine output, energy balance and the diffusion of blood-born molecules …

Background Tumor-infiltrating immune cells (TIICs) are highly relevant to clinical outcome of
glioma. However, previous studies cannot account for the diverse functions that make up the …

Glioblastoma (GBM), one of the most aggressive forms of brain cancer, has limited treatment
options. Recent years have witnessed the remarkable success of checkpoint inhibitor …