Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

Suicide and major depressive disorder (MDD) are complex conditions that almost certainly
arise from the influences of many interrelated factors. There are significant regional …

Worldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by
suicide may be preventable, it is well documented that despite major governmental and …

Depressed mood, which can occur in the context of major depressive disorder, bipolar
disorder, and other conditions, represents a serious threat to public health and wellness …

Multiple studies suggest that the risks of depression and suicide increase with increasing
altitude of residence, but no studies have assessed whether changing altitude changes …

Abstract Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor that regulates gene
expressions in response to decreased oxygen levels in the tissue, or hypoxia. HIF-1 exerts …

Neuroplasticity and connectivity in the central nervous system (CNS) are easily damaged
after hypoxia. Long-term exposure to an anoxic environment can lead to neuropsychiatric …

Introduction Depression is a public health concern, nearing 1.5 million cases and
accounting for 9.7% of years lost due to disability. Several factors, including altitude …

Abstract Kanekar, Shami, Olena V. Bogdanova, Paul R. Olson, Young-Hoon Sung, Kristen E.
D'Anci, and Perry F. Renshaw. Hypobaric hypoxia induces depression-like behavior in …

Background Gut microbiota is significantly influenced by altitude. However, the dynamics of
gut microbiota in relation to altitude remains undisclosed. Methods In this study, we …