Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions
C Gabay, JE Towne - Journal of Leucocyte Biology, 2015 - academic.oup.com
Abstract IL-36α, IL-36β, and IL-36γ are members of the IL-1 family of cytokines that signal
through a common receptor composed of IL-36R and IL-1R/AcP to activate NF-κB and …
through a common receptor composed of IL-36R and IL-1R/AcP to activate NF-κB and …
Asthma and COPD: basic mechanisms and clinical management
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management
continues to provide a unique and authoritative comparison of asthma and COPD. Written …
continues to provide a unique and authoritative comparison of asthma and COPD. Written …
Genome-wide genetic association of complex traits in heterogeneous stock mice
Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress
in the molecular dissection of complex traits in mice. Here we show that genome-wide high …
in the molecular dissection of complex traits in mice. Here we show that genome-wide high …
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
IP Lewkowich, NS Herman, KW Schleifer… - The Journal of …, 2005 - rupress.org
The role of natural CD4+ CD25+ regulatory T (T reg) cells in the control of allergic asthma
remains poorly understood. We explore the impact of T reg cell depletion on the allergic …
remains poorly understood. We explore the impact of T reg cell depletion on the allergic …
Positional cloning of a novel gene influencing asthma from chromosome 2q14
M Allen, A Heinzmann, E Noguchi, G Abecasis… - Nature …, 2003 - nature.com
Asthma is a common disease in children and young adults. Four separate reports have
linked asthma and related phenotypes to an ill-defined interval between 2q14 and 2q32 …
linked asthma and related phenotypes to an ill-defined interval between 2q14 and 2q32 …
Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway
F Schmidlin, S Amadesi, K Dabbagh… - The Journal of …, 2002 - journals.aai.org
Trypsin and mast cell tryptase can signal to epithelial cells, myocytes, and nerve fibers of the
respiratory tract by cleaving proteinase-activated receptor 2 (PAR2). Since tryptase inhibitors …
respiratory tract by cleaving proteinase-activated receptor 2 (PAR2). Since tryptase inhibitors …
Hazardous air pollutants and asthma.
GD Leikauf - Environmental Health Perspectives, 2002 - ehp.niehs.nih.gov
Asthma has a high prevalence in the United States, and persons with asthma may be at
added risk from the adverse effects of hazardous air pollutants (HAPs). Complex mixtures …
added risk from the adverse effects of hazardous air pollutants (HAPs). Complex mixtures …
Mouse model of airway remodeling: strain differences
K Shinagawa, M Kojima - American journal of respiratory and critical …, 2003 - atsjournals.org
We found that continuous eosinophilic inflammation after repeated antigen instillation into
the nose was observed only in A/J mice, not in three other strains. Histologic analysis of …
the nose was observed only in A/J mice, not in three other strains. Histologic analysis of …
A genome-wide association study on African-ancestry populations for asthma
BACKGROUND: Asthma is a complex disease characterized by striking ethnic disparities
not explained entirely by environmental, social, cultural, or economic factors. Of the limited …
not explained entirely by environmental, social, cultural, or economic factors. Of the limited …
In silico mapping of complex disease-related traits in mice
A Grupe, S Germer, J Usuka, D Aud, JK Belknap… - Science, 2001 - science.org
Experimental murine genetic models of complex human disease show great potential for
understanding human disease pathogenesis. To reduce the time required for analysis of …
understanding human disease pathogenesis. To reduce the time required for analysis of …