Arachidonic acid (AA) pathway, a metabolic process, plays a key role in carcinogenesis.
Hence, AA pathway metabolic enzymes phospholipase A 2 s (PLA 2 s), cyclooxygenases …

Recently, there is growing interest in the natural bioactive components having anticancer
activity. Thymoquinone (TQ), the principle active constituent of black seed (Nigella sativa) …

Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective
effects. Interest in this compound has been renewed in recent years, first from its …

The main function of the mammalian immune system is to monitor tissue homeostasis, to
protect against invading or infectious pathogens and to eliminate damaged cells. Therefore …

Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) show opposing roles
in the immune system. In the present study, we report that the establishment of a positive …

Signals mediated by CXCL12 (SDF1) and its receptor CXCR4 are centrally involved in
cancer progression, both directly by activating cancer cells and indirectly by inducing …

Prostate cancer (PC) is the most common cancer in men and the second leading cause of
cancer-related death worldwide. Many therapeutic advances over the last two decades have …

Ochratoxin A (OTA) is a ubiquitous mycotoxin produced by fungi of improperly stored food
products. OTA is nephrotoxic and is suspected of being the main etiological agent …

Calcitriol, the hormonally active form of vitamin D, is being evaluated in clinical trials as an
anti-cancer agent. Calcitriol exerts multiple anti-proliferative, pro-apoptotic, and pro …

Epigenetic disorders such as point mutations in cellular tumor suppressor genes, DNA
methylation and post-translational modifications are needed to transformation of normal …