Breast cancer poses a serious public health problem, and it is hoped that identification of
genetic and environmental factors that contribute to the development of breast cancer will …

Homologous recombination has been recognized in recent years to be an important DNA
repair pathway in mammalian cells, for such damage as chromosomal double-strand …

The Rad51 protein, a eukaryotic homologue of Escherichia coli RecA, plays a central role in
both mitotic and meiotic homologous DNA recombination (HR) in Saccharomyces cerevisiae …

Since BRCA1 and BRCA2 were cloned five years ago, unraveling their normal functions has
posed fascinating problems for cancer biologists. Both genes are novel, and little of their …

Germ-line mutations in the human BRCA2 gene confer susceptibility to breast cancer. Efforts
to elucidate its function have revealed a putative transcriptional activation domain and in …

Individuals carrying a germ line mutation of the breast cancer susceptibility gene BRCA2 are
predisposed to breast, ovarian, and other types of cancer. The BRCA2 protein has been …

There are several lines of evidence indicating that the carboxy-terminal region of the tumor
suppressor protein BRCA1 is a functionally significant domain. Using the yeast two-hybrid …

BRCA2 mutations predispose carriers mainly to breast cancer. The vast majority of BRCA2
mutations are predicted to result in a truncated protein product. The smallest known cancer …

Inherited mutations of the human BRCA2 gene confer increased risks for developing breast,
ovarian, and several other cancers. Unlike previously described Brca2 knockout mice that …

The BRCA2 tumor suppressor plays significant roles in DNA damage response. The human
actin binding protein filamin-1 (hsFLNa, also known as ABP-280) participates in orthogonal …