Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Background Atopic dermatitis (AD) is a prevalent inflammatory skin disease with a complex
pathogenesis involving immune cell and epidermal abnormalities. Despite whole tissue …

The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Inflammation of non-barrier immunologically quiescent tissues is associated with a massive
influx of blood-borne innate and adaptive immune cells. Cues from the latter are likely to …

The tumor microenvironment (TME) in gastric cancer (GC) has been shown to be important
for tumor control but the specific characteristics for GC are not fully appreciated. We …

Activation of fibroblasts is a key event during normal tissue repair after injury and the
dysregulated repair processes that result in organ fibrosis. To most researchers, fibroblasts …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Crohn's disease is a chronic inflammatory intestinal disease that is frequently accompanied
by aberrant healing and stricturing complications. Crosstalk between activated myeloid and …