Protein and phosphoinositide kinases have been successfully exploited as drug targets in
various disease areas, principally in oncology. In malaria, several protein kinases are under …

Malaria remains a heavy public health and socioeconomic burden in tropical and
subtropical regions. Increasing resistance against front-line treatments implies that novel …

Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the
detailed mechanisms underlying its regulation remain to be deciphered. Here, we report the …

Gnathostoma spinigerum is the most common cause of gnathostomiasis in humans. It has a
complex life cycle, which requires two intermediate hosts and a definitive host, and poses a …

Pseudokinases play key roles in many biological processes but they are poorly understood
compared to active kinases. Eight putative pseudokinases have been predicted in …

There is high importance for the control of parasite Plasmodium falciparum which is
responsible for causing malaria. Following the classical mevalonate pathway, the metabolite …

One of the key components in the malaria control is the artemisinin-based combination
therapies. However, the recent and convergent studies indicating a reduced parasite …

Na história da medicina, a malária é uma das doenças parasitárias mais graves e
distribuídas que afetam seres humanos. A doença é causada por parasitas do gênero …

Malaria is caused by parasites from Plasmodium genus and its gametogenesis is an
essential step to ensure the malaria transmission. In efforts to improve the knowledge on …