Recent advances in microbial diagnostics are providing clinicians with information about
microbes causing infections and their resistance to antimicrobial agents more rapidly than …

Diagnostic stewardship means ordering the right tests for the right patient at the right time to
inform optimal clinical care. Diagnostic stewardship is an integral part of antibiotic …

Objective Previously published guidelines provided comprehensive recommendations for
detecting and preventing healthcare-associated infections (HAIs). The intent of this …

Importance Blood culture overuse in the pediatric intensive care unit (PICU) can lead to
unnecessary antibiotic use and contribute to antibiotic resistance. Optimizing blood culture …

Clostridium difficile is a leading cause of antibiotic-associated diarrhea worldwide. The
diagnosis of C. difficile infection (CDI) requires both clinical manifestations and a positive …

Antimicrobial resistance (AMR) has been exacerbated by the inappropriate use of
diagnostics, leading to excessive prescription of antimicrobials, and is an imminent threat to …

Background We used an ultrasensitive, quantitative single molecule array (Simoa)
immunoassay to test whether concentrations of Clostridioides (formerly Clostridium) difficile …

Background Limited information is available on the natural history of Clostridioides difficile
colonization and infection in patients with new acquisition of C. difficile in healthcare …

There is no stand-alone Clostridium difficile diagnostic that can sensitively and rapidly detect
fecal free toxins. We investigated the performance of the C. difficile PCR cycle threshold (CT) …

Clostridium (reclassified as “Clostridioides”) difficile is an anaerobic, gram-positive
bacterium that causes significant disease through elaboration of two potent toxins in patients …