The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …

Background Chronic cerebral hypoperfusion (CCH) underlies secondary brain injury
following certain metabolic disorders and central nervous system (CNS) diseases …

Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …

Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

It has been known for decades that degeneration of the locus coeruleus (LC), the major
noradrenergic nucleus in the brain, occurs in both Alzheimer's disease (AD) and Parkinson's …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

For decades, numerous seminal studies have built our understanding of the locus coeruleus
(LC), the vertebrate brain's principal noradrenergic system. Containing a numerically small …

α1-adrenergic receptors are G-Protein Coupled Receptors that are involved in
neurotransmission and regulate the sympathetic nervous system through binding and …