Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
Mechanisms of action and persistent neuroplasticity by drugs of abuse
ER Korpi, B den Hollander, U Farooq… - Pharmacological …, 2015 - ASPET
Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …
important for the homeostasis of brain processes and for learning and remembering …
Prefrontal dopamine D1 and D2 receptors regulate dissociable aspects of decision making via distinct ventral striatal and amygdalar circuits
NL Jenni, JD Larkin, SB Floresco - Journal of Neuroscience, 2017 - Soc Neuroscience
Mesocortical dopamine (DA) regulates a variety of cognitive functions via actions on D1
and/or D2 receptors. For example, risk/reward decision making is modulated differentially by …
and/or D2 receptors. For example, risk/reward decision making is modulated differentially by …
Role of projections between piriform cortex and orbitofrontal cortex in relapse to fentanyl seeking after palatable food choice-induced voluntary abstinence
DJ Reiner, OM Lofaro, SV Applebey… - Journal of …, 2020 - Soc Neuroscience
We recently developed a rat model of relapse to drug seeking after food choice-induced
voluntary abstinence. Here, we used this model to study the role of the orbitofrontal cortex …
voluntary abstinence. Here, we used this model to study the role of the orbitofrontal cortex …
Organization of afferents to the orbitofrontal cortex in the rat
MJM Murphy, AY Deutch - Journal of Comparative Neurology, 2018 - Wiley Online Library
The prefrontal cortex (PFC) is usually defined as the frontal cortical area receiving a
mediodorsal thalamic (MD) innervation. Certain areas in the medial wall of the rat frontal …
mediodorsal thalamic (MD) innervation. Certain areas in the medial wall of the rat frontal …
Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms
Addiction is a chronic relapsing disorder, in that most addicted individuals who choose to
quit taking drugs fail to maintain abstinence in the long-term. Relapse is especially likely …
quit taking drugs fail to maintain abstinence in the long-term. Relapse is especially likely …
The mesolimbic dopamine activity signatures of relapse to alcohol-seeking
The mesolimbic dopamine system comprises distinct compartments supporting different
functions in learning and motivation. Less well understood is how complex addiction-related …
functions in learning and motivation. Less well understood is how complex addiction-related …
Role of corticostriatal circuits in context-induced reinstatement of drug seeking
Drug addiction is characterized by persistent relapse vulnerability during abstinence. In
abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts …
abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts …
A cocaine context renews drug seeking preferentially in a subset of individuals
BT Saunders, EG O'donnell, EL Aurbach… - …, 2014 - nature.com
Addiction is characterized by a high propensity for relapse, in part because cues associated
with drugs can acquire Pavlovian incentive motivational properties, and acting as incentive …
with drugs can acquire Pavlovian incentive motivational properties, and acting as incentive …
The winding road to relapse: forging a new understanding of cue-induced reinstatement models and their associated neural mechanisms
In drug addiction, cues previously associated with drug use can produce craving and
frequently trigger the resumption of drug taking in individuals vulnerable to relapse …
frequently trigger the resumption of drug taking in individuals vulnerable to relapse …