Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications

J Zhang, J Zhang, C Zhang, J Zhang, L Gu, D Luo… - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and
blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the …

Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

R Simo, C Hernández - Trends in Endocrinology & Metabolism, 2014 - cell.com
Diabetic retinopathy (DR), one of the leading causes of preventable blindness, has been
considered a microcirculatory disease of the retina. However, there is emerging evidence to …

[HTML][HTML] Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

ZY Tang, Y Li, YT Tang, XD Ma, ZY Tang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Oleanolic acid (OA, 3 β-hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic
triterpenoid present in many plants. As a new framework for development of semi synthetic …

Post-translational modifications: regulators of neurodegenerative proteinopathies

R Gupta, M Sahu, D Srivastava, S Tiwari… - Ageing Research …, 2021 - Elsevier
One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer

J Sun, X Cai, MMH Yung, W Zhou, J Li, Y Zhang, Z Li… - Oncogene, 2019 - nature.com
Platinum drugs are used in first-line to treat ovarian cancer, but most of the patients
eventually generate resistance after treatment with these drugs. Although both c-Myc and …

Unexpected benefits of intermittent hypoxia: enhanced respiratory and nonrespiratory motor function

EA Dale, F Ben Mabrouk, GS Mitchell - Physiology, 2014 - journals.physiology.org
Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-
disordered breathing, including central nervous system pathology. However, recent …

Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury

M Schoeler, PD Loetscher, R Rossaint… - BMC neurology, 2012 - Springer
Background The α 2-adrenoreceptor agonist dexmedetomidine is known to provide
neuroprotection under ischemic conditions. In this study we investigated whether …

Diabetic retinal neurodegeneration as a form of diabetic retinopathy

D Soni, P Sagar, B Takkar - International Ophthalmology, 2021 - Springer
Purpose To review the evidence supporting diabetic retinal neurodegeneration (DRN) as a
form of diabetic retinopathy. Method Review of literature. Results DRN is recognized to be a …

[HTML][HTML] Molecular biological mechanism of action in cancer therapies: Juglone and its derivatives, the future of development

YT Tang, Y Li, P Chu, XD Ma, ZY Tang… - Biomedicine & …, 2022 - Elsevier
Abstract Juglone (5-hydroxy-1, 4-naphthalene diketone) is a kind of natural
naphthoquinone, present in the roots, leaves, nut-hulls, bark and wood of walnut trees …

From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and disease

C Caprara, C Grimm - Progress in retinal and eye research, 2012 - Elsevier
Photoreceptors and other cells of the retina consume large quantities of energy to efficiently
convert light information into a neuronal signal understandable by the brain. The necessary …