Mutations in the family of neurexins (NRXN1, NRXN2 and NRXN3) have been repeatedly
identified in patients with autism spectrum disorder (ASD) and schizophrenia (SCZ) …

As an important part in international disease, mental disorders seriously damage human
health and social stability, which show the complex pathogenesis and increasing incidence …

Scoliosis is a common spinal deformity that considerably affects the physical and
psychological health of patients. Studies have shown that genetic factors play an important …

Importance Genome-wide association studies (GWASs) in European populations have
identified more than 100 schizophrenia-associated loci. A schizophrenia GWAS in a unique …

The embryonic notochord is a flexible structure present during development that serves as
scaffold for formation of the vertebrate spine. This rod-like organ is thought to have evolved …

Rare genetic diseases are a group of pathologies with often unmet clinical needs. Even if
rare by a single genetic disease (from 1/2000 to 1/more than 1,000,000), the total number of …

The neurodegenerative disease Machado–Joseph disease (MJD), also known as
spinocerebellar ataxin-3, affects neurons of the brain and spinal cord, disrupting control of …

Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease
characterized by the selective death of lower motor neurons in the brain stem and spinal …

Most neurodegenerative diseases are currently incurable, with large social and economic
impacts. Recently, there has been renewed interest in investigating natural products in the …

Wolfram syndrome (WS) is a rare genetic disease characterized by diabetes, optic atrophy
and deafness. Patients die at 35 years of age, mainly from respiratory failure or dysphagia …