Potential applications of extracellular vesicles (EVs) are attracting increasing interest in the
fields of medicine, cosmetics, and nutrition. However, the manufacturing of EVs is currently …

Therapies based on injecting living cells into patients offer a huge potential to cure many
degenerative and deadly diseases, with hundreds of clinical trials ongoing. Due to their …

Microfluidic devices have shown promising applications in the bioprocessing industry.
However, the lack of modularity and high cost of testing and error limit their implementation …

Stem cell–based cell therapeutics and especially those based on human mesenchymal
stem cells (hMSCs) and induced pluripotent stem cells (hiPSCs) are said to have enormous …

Highlights•Overview of analytics for characterization of stem cells' critical quality
attributes.•Highlight the main challenges for definition of stem cell potency.•Outline the role …

Featured Application Biomedical product development from PEF application into platelets.
Abstract Nowadays, the standard media used in clinical-scale mesenchymal stem cell …

Cell therapy manufacturing requires precise monitoring of critical parameters to ensure
product quality, consistency and to facilitate the implementation of cost-effective processes …

The formulation of cell-based medicinal products (CBMPs) poses major challenges because
of their complexity, heterogeneity, interaction with their environment (eg, the formulation …

This manuscript discusses the role of process systems engineering (PSE) in ensuring quality
manufacturing of Mesenchymal Stem Cells (MSCs) through seeding, cultivation, and …

This study presents new injectable hydrogels based on hyaluronic acid and collagen type II
that mimic the polysaccharide-protein structure of natural cartilage. After collagen isolation …