Recombination, pairing, and synapsis of homologs during meiosis
D Zickler, N Kleckner - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
Recombination is a prominent feature of meiosis in which it plays an important role in
increasing genetic diversity during inheritance. Additionally, in most organisms …
increasing genetic diversity during inheritance. Additionally, in most organisms …
Mechanism and regulation of meiotic recombination initiation
I Lam, S Keeney - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Meiotic recombination involves the formation and repair of programmed DNA double-strand
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …
breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent …
Initial sequencing and analysis of the human genome
US DOE Joint Genome Institute: Hawkins Trevor 4 … - Nature, 2001 - nature.com
The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …
physiology, medicine and evolution. Here we report the results of an international …
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
F Pâques, JE Haber - Microbiology and molecular biology reviews, 1999 - Am Soc Microbiol
The budding yeast Saccharomyces cerevisiae has been the principal organism used in
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …
Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease
P Rouet, F Smih, M Jasin - Molecular and cellular biology, 1994 - Taylor & Francis
To maintain genomic integrity, double-strand breaks (DSBs) in chromosomal DNA must be
repaired. In mammalian systems, the analysis of the repair of chromosomal DSBs has been …
repaired. In mammalian systems, the analysis of the repair of chromosomal DSBs has been …
[HTML][HTML] A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation
The nonrandom distribution of meiotic recombination influences patterns of inheritance and
genome evolution, but chromosomal features governing this distribution are poorly …
genome evolution, but chromosomal features governing this distribution are poorly …
Genetic recombination is directed away from functional genomic elements in mice
Genetic recombination occurs during meiosis, the key developmental programme of
gametogenesis. Recombination in mammals has been recently linked to the activity of a …
gametogenesis. Recombination in mammals has been recently linked to the activity of a …
Nucleosomes and DNA methylation shape meiotic DSB frequency in Arabidopsis thaliana transposons and gene regulatory regions
Meiotic recombination initiates from DNA double-strand breaks (DSBs) generated by SPO11
topoisomerase-like complexes. Meiotic DSB frequency varies extensively along eukaryotic …
topoisomerase-like complexes. Meiotic DSB frequency varies extensively along eukaryotic …
Arabidopsis meiotic crossover hot spots overlap with H2A.Z nucleosomes at gene promoters
PRDM9 directs human meiotic crossover hot spots to intergenic sequence motifs, whereas
budding yeast hot spots overlap regions of low nucleosome density (LND) in gene …
budding yeast hot spots overlap regions of low nucleosome density (LND) in gene …
Genome architecture, rearrangements and genomic disorders
P Stankiewicz, JR Lupski - TRENDS in Genetics, 2002 - cell.com
An increasing number of human diseases are recognized to result from recurrent DNA
rearrangements involving unstable genomic regions. These are termed genomic disorders …
rearrangements involving unstable genomic regions. These are termed genomic disorders …