Inflammation and tumor progression: signaling pathways and targeted intervention
H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …
either promotes or suppresses tumor progression, potentially displaying opposing effects on …
Leishmaniasis: complexity at the host–pathogen interface
P Kaye, P Scott - Nature reviews microbiology, 2011 - nature.com
Leishmania is a genus of protozoan parasites that are transmitted by the bite of
phlebotomine sandflies and give rise to a range of diseases (collectively known as …
phlebotomine sandflies and give rise to a range of diseases (collectively known as …
CD8+ T Cells in Leishmania Infections: Friends or Foes?
S Stäger, S Rafati - Frontiers in immunology, 2012 - frontiersin.org
Host protection against several intracellular pathogens requires the induction of CD8+ T cell
responses. CD8+ T cells are potent effector cells that can produce high amounts of pro …
responses. CD8+ T cells are potent effector cells that can produce high amounts of pro …
Methods for controlling T cell proliferation
T cells express receptors on their surfaces (ie, T cell receptors) that recognize antigens
presented on the surface of antigen-presenting cells. During a normal immune response …
presented on the surface of antigen-presenting cells. During a normal immune response …
CD40-mediated activation of the NF-κB2 pathway
BS Hostager, GA Bishop - Frontiers in immunology, 2013 - frontiersin.org
CD40 is a critical stimulatory receptor on antigen-presenting cells of the immune system.
CD40-mediated activation of B cells is particularly important for normal humoral immune …
CD40-mediated activation of B cells is particularly important for normal humoral immune …
CD40 expression levels modulate regulatory T cells in Leishmania donovani infection
S Martin, R Agarwal, G Murugaiyan… - The Journal of …, 2010 - journals.aai.org
Dendritic cell (DC)-expressed CD40 is shown to play crucial roles in eliciting effector T cell
responses, primarily the proinflammatory CD4+ Th subsets and cytotoxic CD8+ T cells that …
responses, primarily the proinflammatory CD4+ Th subsets and cytotoxic CD8+ T cells that …
Methods for controlled elimination of therapeutic cells
QFJCIRLUMZQUOT-HPLJOQBZSA-N Sirolimus Chemical compound C1C [C@@ H](O)[C@
H](OC) C [C@@ H] 1C [C@@ H](C)[C@ H] 1OC (= O)[C@@ H] 2CCCCN2C (= O) C …
H](OC) C [C@@ H] 1C [C@@ H](C)[C@ H] 1OC (= O)[C@@ H] 2CCCCN2C (= O) C …
CXCL10 is critical for the generation of protective CD8 T cell response induced by antigen pulsed CpG-ODN activated dendritic cells
S Majumder, S Bhattacharjee, B Paul Chowdhury… - PLoS …, 2012 - journals.plos.org
The visceral form of leishmaniasis is the most severe form of the disease and of particular
concern due to the emerging problem of HIV/visceral leishmaniasis (VL) co-infection in the …
concern due to the emerging problem of HIV/visceral leishmaniasis (VL) co-infection in the …
Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12
2016-01-15 Assigned to BELLICUM PHARMACEUTICALS, INC. reassignment BELLICUM
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Pegylated bisacycloxypropylcysteine, a diacylated lipopeptide ligand of TLR6, plays a host-protective role against experimental Leishmania major infection
SP Pandey, HS Chandel, S Srivastava… - The Journal of …, 2014 - journals.aai.org
TLRs recognize pathogen-expressed Ags and elicit host-protective immune response.
Although TLR2 forms heterodimers with TLR1 or TLR6, recognizing different ligands …
Although TLR2 forms heterodimers with TLR1 or TLR6, recognizing different ligands …