Principles of fluoride toxicity and the cellular response: a review

NR Johnston, SA Strobel - Archives of toxicology, 2020 - Springer
Fluoride is ubiquitously present throughout the world. It is released from minerals, magmatic
gas, and industrial processing, and travels in the atmosphere and water. Exposure to low …

Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches

AH Nagendra, B Bose, S Shenoy P - Molecular Biology Reports, 2021 - Springer
Fluoride is a natural element essential in minute quantities in human's to maintain dental
and skeletal health. However, the disease fluorosis manifests itself due to excessive fluoride …

[HTML][HTML] Fluoride enhances generation of reactive oxygen and nitrogen species, oxidizes hemoglobin, lowers antioxidant power and inhibits transmembrane electron …

N Maheshwari, N Qasim, R Anjum… - … and Environmental Safety, 2021 - Elsevier
Fluoride is a widespread environmental pollutant that at high levels exerts numerous
deleterious effects on human health. The toxic effects of fluoride are a matter of serious …

Fluoride induced mitochondrial impairment and PINK1-mediated mitophagy in Leydig cells of mice: In vivo and in vitro studies

C Liang, Y Gao, Y He, Y Han, RK Manthari, C Tikka… - Environmental …, 2020 - Elsevier
It is very important to explore the potential harm and underlying mechanism of fluoride due
to the extensive distribution and the significant health risks of fluoride in environment. The …

Impact of chronic sodium fluoride toxicity on antioxidant capacity, biochemical parameters, and histomorphology in cardiac, hepatic, and renal tissues of wistar rats

P Sharma, PK Verma, S Sood, M Singh… - Biological Trace Element …, 2023 - Springer
The study was designed to determine the fluoride distribution after its oral exposure in
drinking water and its associated impact on biochemical, antioxidant markers and histology …

Fluoride induces apoptosis in mammalian cells: in vitro and in vivo studies

DA Ribeiro, CM Cardoso, VQ Yujra… - Anticancer …, 2017 - ar.iiarjournals.org
Apoptosis is genetically programmed cell death, an irreversible process of cell senescence
with characteristic features different from other cellular mechanisms of death such as …

Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor α …

SJ In, SH Kim, RE Go, KA Hwang… - Journal of Toxicology and …, 2015 - Taylor & Francis
Endocrine-disrupting chemicals (EDC) are defined as environmental compounds that
produce adverse health manifestations in mammals by disrupting the endocrine system …

Evaluation of vascular and kidney injury biomarkers in Mexican children exposed to inorganic fluoride

MI Jiménez-Córdova, C González-Horta… - Environmental …, 2019 - Elsevier
Exposure to inorganic fluoride (F) has been implicated in cardiovascular and kidney
dysfunction mainly in adult populations. However, limited epidemiological information from …

[HTML][HTML] Sodium fluoride arrests renal G2/M phase cell-cycle progression by activating ATM-Chk2-P53/Cdc25C signaling pathway in mice

Q Luo, H Guo, P Kuang, H Cui, H Deng, H Liu… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Excessive fluoride intake can induce cytotoxicity, DNA damage and cell-
cycle changes in many tissues and organs, including the kidney. However, the underlying …

Mitochondrial-targeted near-infrared fluorescence probe for selective detection of fluoride ions in living cells

X Xu, W Chen, M Yang, XJ Liu, F Wang, RQ Yu… - Talanta, 2019 - Elsevier
Abstract Fluoride ions (F−), as a strongest electron withdrawing anion of the smallest size,
have played an indispensable role in biological systems. Here a mitochondria-targeted near …