Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …

Metastatic uveal melanoma (mUM) has historically been associated with short survival and
limited effective treatments. Immune checkpoint inhibitors (ICIs) have been trialed in mUM; …

Polygenic risk scores are becoming increasingly predictive of complex traits, but their
suboptimal performance in non-European ancestry populations raises questions about their …

Time-to-event (T2E) analysis is a branch of statistics that models the duration of time it takes
for an event to occur. Such events can include outcomes like death, unemployment, or …

In causal studies, the near‐violation of the positivity may occur by chance, because of
sample‐to‐sample fluctuation despite the theoretical veracity of the positivity assumption in …

Background Patients with chronic obstructive pulmonary disease (COPD) have poor
outcomes in the setting of community-acquired pneumonia (CAP) and severe acute …

Males and females rarely express the same length of life. Here, we studied how sociosexual
exposure shapes male and female age-specific mortality rates in Drosophila melanogaster …

Polygenic risk scores (PRS) enhance population risk stratification and advance
personalized medicine, but existing methods face several limitations, encompassing issues …

We compare two multi-state modelling frameworks that can be used to represent dates of
events following hospital admission for people infected during an epidemic. The methods …

Background and purpose Therapeutic management of relapsing–remitting multiple sclerosis
(RRMS) has evolved towards early treatment. The objective was to assess the impact of …