The tetrahydroisoquinoline (THIQ) natural products constitute one of the largest families of
alkaloids and exhibit a wide range of structural diversity and biological activity. Ranging from …

Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Marine life forms are an important source of structurally diverse and biologically active
secondary metabolites, several of which have inspired the development of new classes of …

Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …

Spurred by advancements in microbial genetics and enzyme engineering, chemoenzymatic
strategies, which combine enzymatic and synthetic transformations, have increasingly made …

In many macroorganisms, the ultimate source of potent biologically active natural products
has remained elusive due to an inability to identify and culture the producing symbiotic …

Pictet–Spenglerases provide a key role in the biosynthesis of many biologically active
alkaloids. There is increasing use of these biocatalysts as an alternative to traditional …

Covering: up to the end of 2020 Nonribosomal peptide synthetases are remarkable
molecular machines that produce a wide range of structurally complex peptide natural …

The Pictet-Spengler reaction (PS) is one of the most direct, efficient, and variable synthetic
method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines …