Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Because telomeres shorten progressively with each replication, they …

In this review article, emphasis is placed on the critical survey of available data concerning
modified nucleobase and 2-deoxyribose products that have been identified in cellular DNA …

The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

Search for the formation of oxidatively base damage in cellular DNA has been a matter of
debate for more than 40years due to the lack of accurate methods for the measurement of …

Emphasis is placed in the first part of this survey on mechanistic aspects of the formation of 8-
oxo-7, 8-dihydroguanine (8-oxoGua) as the result of exposure to OH radical, one-electron …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Mutations in genes on the nucleotide excision repair pathway are associated with diseases,
such as xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy, that involve …

Nuclear DNA and other molecules in living systems are continuously exposed to
endogenously generated oxygen species. Such species range from the unreactive …

Endogenous and exogenous sources cause oxidatively induced DNA damage in living
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …

Significance: Oxidative DNA damage is repaired by multiple, overlapping DNA repair
pathways. Accumulating evidence supports the hypothesis that nucleotide excision repair …