Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are
poised to transduce signals emanating from the cell surface. Cell membranes provide the …

The discovery in the early 1980s that protein kinase C is 'the receptor'for the tumor-
promoting phorbol esters catapulted this enzyme to the forefront of research in signal …

Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase)
activity 12‐fold in L6 myotubes, while after transfection into 293 cells PKBalpha was …

Phosphorylation plays a central role in regulating the activation and signalling lifetime of
protein kinases A, B (also known as Akt) and C. These kinases share three conserved …

Protein kinase C has been in the spotlight since the discovery two decades ago that is
activated by the lipid second messenger diacylglycerol. Despite protein kinase C's enduring …

Protein kinase C (PKC) isoforms, α, βI, and γ of cPKC subgroup, δ and ɛ of nPKC subgroup,
and ζ of aPKC subgroup, were tyrosine phosphorylated in COS-7 cells in response to H2O2 …

Abstract Background: Protein kinase Cs are a family of enzymes that transduce the plethora
of signals promoting lipid hydrolysis. Here, we show that protein kinase C must first be …

Background: Protein kinase C ζ (PKCζ) is a member of the PKC family of enzymes and is
involved in a wide range of physiological processes including mitogenesis, protein …

The protein kinase C (PKC) family of signal transducers are characterized by a dependence
upon lipids for activity. Specifically, the classical (cPKCα, β and γ) and novel (nPKCδ, ϵ, η …

Background: Phosphorylation critically regulates the catalytic function of most members of
the protein kinase superfamily. One such member, protein kinase C (PKC), contains two …