Biological roles of adenine methylation in RNA
K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
RNA modifications in physiology and disease: towards clinical applications
The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
[HTML][HTML] The proteins of mRNA modification: writers, readers, and erasers
MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …
expression control in cells. Fueled in large part by the development of tools for detecting …
[HTML][HTML] N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
RM2Target: a comprehensive database for targets of writers, erasers and readers of RNA modifications
X Bao, Y Zhang, H Li, Y Teng, L Ma… - Nucleic Acids …, 2023 - academic.oup.com
RNA modification is a dynamic and reversible process regulated by a series of writers,
erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification …
erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification …
N6-methyladenosine-mediated gene regulation and therapeutic implications
Y Liu, D Yang, T Liu, J Chen, J Yu, P Yi - Trends in molecular medicine, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …
modification in eukaryotes and is at the front line of biological and biomedical research. This …
[HTML][HTML] Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis
Light regulates chlorophyll homeostasis and photosynthesis via various molecular
mechanisms in plants. The light regulation of transcription and protein stability of nuclear …
mechanisms in plants. The light regulation of transcription and protein stability of nuclear …
The role of alternative splicing in adaptation and evolution
Regulation of gene expression plays a central role in adaptive divergence and evolution.
Although the role of gene regulation in microevolutionary processes is gaining wide …
Although the role of gene regulation in microevolutionary processes is gaining wide …
[HTML][HTML] FIONA1 is an RNA N6-methyladenosine methyltransferase affecting Arabidopsis photomorphogenesis and flowering
C Wang, J Yang, P Song, W Zhang, Q Lu, Q Yu, G Jia - Genome Biology, 2022 - Springer
Abstract Background N 6-methyladenosine (m6A) mRNA modification is essential for
mammalian and plant viability. The U6 m6A methyltransferases in other species regulate S …
mammalian and plant viability. The U6 m6A methyltransferases in other species regulate S …