Biological roles of adenine methylation in RNA

K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …

RNA modifications in physiology and disease: towards clinical applications

S Delaunay, M Helm, M Frye - Nature Reviews Genetics, 2024 - nature.com
The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects

ME Rogalska, C Vivori, J Valcárcel - Nature Reviews Genetics, 2023 - nature.com
The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

[HTML][HTML] The proteins of mRNA modification: writers, readers, and erasers

MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …

[HTML][HTML] N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …

RM2Target: a comprehensive database for targets of writers, erasers and readers of RNA modifications

X Bao, Y Zhang, H Li, Y Teng, L Ma… - Nucleic Acids …, 2023 - academic.oup.com
RNA modification is a dynamic and reversible process regulated by a series of writers,
erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification …

N6-methyladenosine-mediated gene regulation and therapeutic implications

Y Liu, D Yang, T Liu, J Chen, J Yu, P Yi - Trends in molecular medicine, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …

[HTML][HTML] Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis

B Jiang, Z Zhong, L Gu, X Zhang, J Wei, C Ye, G Lin… - Nature Plants, 2023 - nature.com
Light regulates chlorophyll homeostasis and photosynthesis via various molecular
mechanisms in plants. The light regulation of transcription and protein stability of nuclear …

The role of alternative splicing in adaptation and evolution

JP Verta, A Jacobs - Trends in Ecology & Evolution, 2022 - cell.com
Regulation of gene expression plays a central role in adaptive divergence and evolution.
Although the role of gene regulation in microevolutionary processes is gaining wide …

[HTML][HTML] FIONA1 is an RNA N6-methyladenosine methyltransferase affecting Arabidopsis photomorphogenesis and flowering

C Wang, J Yang, P Song, W Zhang, Q Lu, Q Yu, G Jia - Genome Biology, 2022 - Springer
Abstract Background N 6-methyladenosine (m6A) mRNA modification is essential for
mammalian and plant viability. The U6 m6A methyltransferases in other species regulate S …