A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

Paclitaxel (PTX) is a widely used chemotherapeutic drug particularly effective against lung,
breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity …

The Wnt/β-catenin signaling pathway is a highly conserved pathway that is involved in cell
development, proliferation, differentiation, apoptosis and autophagy. Among these …

Although surgery with or without (neo) adjuvant chemo/radiotherapy, as the standard
treatments, can be suitable therapeutic strategies for gastric cancer, side effects and drug …

G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in
recent years as novel targets, with untapped potential for anticancer research. Their …

For centuries, plants have been exploited by mankind as sources of numerous cancer
chemotherapeutic agents. Good examples of anticancer compounds of clinical significance …

Introduction Guanine-rich DNA sequences can fold into four-stranded noncanonical
secondary structures called G-quadruplexes (G4s) which are widely distributed in functional …

Osteosarcoma is the most common type of pediatric bone tumor. Despite great advances in
chemotherapy during the past decades, the survival rates of osteosarcoma patients remain …

The incidence of oral cancer is increasing due to smoking, drinking, and human
papillomavirus (HPV) infection, while the current treatments are not satisfactory. Small …