Phosphoribosyl diphosphate (PRPP) is an important intermediate in cellular metabolism.
PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate+ ATP→ PRPP+ …

Members of the homologous PRT family are catalytic and regulatory proteins involved in
nucleotide synthesis and salvage. New crystal structures have revealed key elements of …

This graduate textbook is aimed at providing researchers new to the subject with information
on the structure and mechanisms in the chemistry, biochemistry or processing of …

Activation of glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase (GPATase)
by binding of a PRPP substrate analog results in the formation of a 20 Å channel connecting …

Hypoxanthine− guanine phosphoribosyltransferase (HGPRTase) is the locus of Lesch-
Nyhan syndrome, the activator of the prodrugs 6-mercaptopurine and allopurinol, and a …

We developed an effective strategy to restrict the amino acid usage in a relatively large
protein to a reduced set with conservation of its in vivo function. The 213-residue …

Orotidine 5 '-monophosphate decarboxylase (ODCase) catalyzes the decarboxylation of
orotidine 5 '-monophosphate, the last step in the de novo synthesis of uridine 5 ' …

We review literature on the metabolism of ribo-and deoxyribonucleotides, nucleosides, and
nucleobases in Escherichia coli and Salmonella, including biosynthesis, degradation …

Millions of deaths worldwide are caused by the aetiological agent of tuberculosis,
Mycobacterium tuberculosis. The increasing prevalence of this disease, the emergence of …

Crystal structures of glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase
from Escherichia coli have been determined to 2.0‐Å resolution in the absence of ligands …