Modeling the within-host dynamics of HIV infection
AS Perelson, RM Ribeiro - BMC biology, 2013 - Springer
The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …
models of human immunodeficiency virus (HIV), but now includes many viral infections …
[图书][B] Mathematical biology: II: spatial models and biomedical applications
JD Murray, JD Murray - 2003 - Springer
It has been over a decade since the release first edition of the now classic original edition of
Murray's Mathematical Biology. Since then mathematical biology and medicine has grown at …
Murray's Mathematical Biology. Since then mathematical biology and medicine has grown at …
Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system
We present a new approach to the study of the immune system that combines techniques of
systems biology with information provided by data-driven prediction methods. To this end …
systems biology with information provided by data-driven prediction methods. To this end …
Mathematical analysis of HIV-1 dynamics in vivo
AS Perelson, PW Nelson - SIAM review, 1999 - SIAM
Mathematical models have proven valuable in understanding the dynamics of HIV-1
infection in vivo. By comparing these models to data obtained from patients undergoing …
infection in vivo. By comparing these models to data obtained from patients undergoing …
Virus dynamics and drug therapy
The recent development of potent antiviral drugs not only has raised hopes for effective
treatment of infections with HIV or the hepatitis B virus, but also has led to important …
treatment of infections with HIV or the hepatitis B virus, but also has led to important …
A model of HIV-1 pathogenesis that includes an intracellular delay
PW Nelson, JD Murray, AS Perelson - Mathematical biosciences, 2000 - Elsevier
Mathematical modeling combined with experimental measurements have yielded important
insights into HIV-1 pathogenesis. For example, data from experiments in which HIV-infected …
insights into HIV-1 pathogenesis. For example, data from experiments in which HIV-infected …
Managing resistance to anti-HIV drugs: an important consideration for effective disease management
AM Vandamme, K Van Laethem, E De Clercq - Drugs, 1999 - Springer
Current recommendations for the treatment of HIV-infected patients advise highly active
antiretroviral therapy (HAART) consisting of combinations of 3 or more drugs to provide long …
antiretroviral therapy (HAART) consisting of combinations of 3 or more drugs to provide long …
Drug concentration heterogeneity facilitates the evolution of drug resistance
TB Kepler, AS Perelson - Proceedings of the National …, 1998 - National Acad Sciences
Pathogenic microorganisms use Darwinian processes to circumvent attempts at their control
through chemotherapy. In the case of HIV-1 infection, in which drug resistance is a …
through chemotherapy. In the case of HIV-1 infection, in which drug resistance is a …
Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection
Mathematical modeling of viral replication dynamics, based on sequential measurements of
levels of virion-associated RNA in plasma during antiretroviral treatment, has led to …
levels of virion-associated RNA in plasma during antiretroviral treatment, has led to …
Emergence of HIV-1 drug resistance during antiretroviral treatment
Treating HIV-infected patients with a combination of several antiretroviral drugs usually
contributes to a substantial decline in viral load and an increase in CD4+ T cells. However …
contributes to a substantial decline in viral load and an increase in CD4+ T cells. However …