Immunological memory is an important evolutionary trait that improves host survival upon
reinfection. Memory is a characteristic recognized within both the innate and adaptive arms …

Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …

Differentiated somatic mammalian cells putatively exhibit species-specific division limits that
impede cancer but may constrain lifespans,–. To provide immunity, transiently stimulated …

T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …

TGFβ signaling is associated with non-response to immune checkpoint blockade in patients
with advanced cancers, particularly in the immune-excluded phenotype. While previous …

Studies of immune system metabolism (" immunometabolism") segregate along two paths.
The first investigates the effects of immune cells on organs that regulate whole-body …

Immunological memory is a cardinal feature of adaptive immunity and an important goal of
vaccination strategies. Here we highlight advances in the understanding of the diverse T …

Chimeric antigen receptor (CAR) T cell therapy has attracted attention for its promising
therapeutic effects on hematological malignancies. However, there are problems such as …

Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …

Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T
cells can mediate tumour regression in patients with metastatic cancer. Here, we discuss …