Open systems can only exist by self-organization as pulsing structures exchanging matter
and energy with the outer world. This review is an attempt to reveal the organizational …

Immunoactinopathies caused by mutations in actin‐related proteins are a growing group of
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …

The mechanisms underlying cancer metastasis remain poorly understood. Here, we report
that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with …

Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that
nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly …

The actin cytoskeleton is of fundamental importance for numerous cellular processes,
including intracellular transport, cell plasticity, and cell migration. However, functions of …

Actin is an essential regulator of cellular functions. In the eukaryotic cell nucleus, actin
regulates chromatin as a bona fide component of chromatin remodelling complexes, it …

The importance of myosin motor protein is well-characterised within the cytoplasm and
cytoskeleton. However, mounting evidence on four nuclear myosins highlights the central …

Actin cytoskeletal dynamics drive cellular shape changes, linking numerous cell functions to
physiological and pathological cues. Mutations in actin regulators that are differentially …

The FERM domain is a conserved and widespread protein module that appeared in the
common ancestor of amoebae, fungi, and animals, and is therefore now found in a wide …

Missense variants throughout ACTA2, encoding smooth muscle α-actin (αSMA), predispose
to adult onset thoracic aortic disease, but variants disrupting arginine 179 (R179) lead to …