Cerebral amyloid angiopathy (CAA), due to vascular amyloid β (Aβ) deposition, is a risk
factor for intracerebral haemorrhage and dementia. CAA can occur in sporadic or rare …

30 Stroke January 2020 resonance imaging (MRI) also added new lesion types to the list of
the classically accepted cSVD-related pathologies. ICH and CMBs in deep-brain regions …

Reconstruction of the vasculature of intact tissues/organs down to the capillary level is
essential for understanding the development and remodeling of vascular networks under …

Tissue optical clearing technology has been developing rapidly in the past decade due to
advances in microscopy equipment and various labeling techniques. Consistent …

While being increasingly recognized in clinical routine, brain microbleeds remain a puzzling
finding for physicians. These small dot-like lesions are thought to be old perivascular …

As a part of the central nervous system, the retina may reflect both physiological processes
and abnormalities related to pathologies that affect the brain. Amyloidosis due to the …

Microhemorrhages are strongly associated with advanced cerebral amyloid angiopathy
(CAA). Although it has been frequently proposed that the deposition of Aβ in the walls of …

Background Cerebral microbleeds (CMBs) are an early sign of many neurological disorders
and accompanied by local neuroinflammation and brain damage. As important regulators of …

Significance: To explore brain architecture and pathology, a consistent and reliable
methodology to visualize the three-dimensional cerebral microvasculature is beneficial …

We have previously demonstrated that the use of a commercially-available immersion-
based optical clearing agent (OCA) enables, within 3–6 hours, three-dimensional …