[HTML][HTML] Targeting energy metabolism in cancer stem cells: progress and challenges in leukemia and solid tumors
Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …
[HTML][HTML] The role of translocator protein TSPO in hallmarks of glioblastoma
Simple Summary The translocator protein (TSPO) has been under extensive investigation as
a specific marker in positron emission tomography (PET) to visualize brain lesions following …
a specific marker in positron emission tomography (PET) to visualize brain lesions following …
[HTML][HTML] Translocator protein (18kDA)(TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated …
L Weidner, J Lorenz, S Quach, FK Braun… - Acta Neuropathologica …, 2023 - Springer
TSPO is a promising novel tracer target for positron-emission tomography (PET) imaging of
brain tumors. However, due to the heterogeneity of cell populations that contribute to the …
brain tumors. However, due to the heterogeneity of cell populations that contribute to the …
[HTML][HTML] TSPO PET signal using [18F]GE180 is associated with survival in recurrent gliomas
S Quach, A Holzgreve, L Kaiser, M Unterrainer… - European Journal of …, 2023 - Springer
Purpose Glioma patients, especially recurrent glioma, suffer from a poor prognosis. While
advances to classify glioma on a molecular level improved prognostication at initial …
advances to classify glioma on a molecular level improved prognostication at initial …
Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
LM Bartos, SV Kirchleitner, ZI Kolabas, S Quach… - Science …, 2023 - science.org
Various cellular sources hamper interpretation of positron emission tomography (PET)
biomarkers in the tumor microenvironment (TME). We developed an approach of …
biomarkers in the tumor microenvironment (TME). We developed an approach of …
[HTML][HTML] Imaging temozolomide-induced changes in the myeloid glioma microenvironment
C Foray, S Valtorta, C Barca, A Winkeler, W Roll… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: The heterogeneous nature of gliomas makes the development and application of
novel treatments challenging. In particular, infiltrating myeloid cells play a role in tumor …
novel treatments challenging. In particular, infiltrating myeloid cells play a role in tumor …
[HTML][HTML] TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma
AN Menevse, LM Ammer, A Vollmann-Zwerenz… - Acta Neuropathologica …, 2023 - Springer
Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly
resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in …
resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in …
[HTML][HTML] L-type amino acid transporter (LAT) 1 expression in 18F-FET-negative gliomas
FJ Vettermann, C Diekmann, L Weidner, M Unterrainer… - EJNMMI research, 2021 - Springer
Abstract Background O-(2-[18 F]-fluoroethyl)-L-tyrosine (18 F-FET) is a highly sensitive PET
tracer for glioma imaging, and its uptake is suggested to be driven by an overexpression of …
tracer for glioma imaging, and its uptake is suggested to be driven by an overexpression of …
[HTML][HTML] Clinical applications of TSPO PET for glioma imaging: Current evidence and future perspective—A systematic review
Our aim was to provide a comprehensive overview of the existing literature concerning the
clinical applications of positron emission computed tomography (PET) with …
clinical applications of positron emission computed tomography (PET) with …
[HTML][HTML] Multi-targeted neutron capture therapy combined with an 18 kDa translocator protein-targeted boron compound is an effective strategy in a rat brain tumor …
H Kashiwagi, Y Hattori, S Kawabata, R Kayama… - Cancers, 2023 - mdpi.com
Simple Summary In recent years, boron neutron capture therapy (BNCT) has attracted
attention as a treatment for high-grade gliomas, and clinical trials using an accelerator …
attention as a treatment for high-grade gliomas, and clinical trials using an accelerator …