Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Having direct access to brain vasculature, astrocytes can take up available blood nutrients
and metabolize them to fulfil their own energy needs and deliver metabolic intermediates to …

Endocannabinoids (eCBs) are retrograde neuromodulators with important functions in a
wide range of physiological processes, but their in vivo dynamics remain largely …

Ischemic stroke is caused by insufficient cerebrovascular blood and oxygen supply. It is a
major contributor to death or disability worldwide and has become a heavy societal and …

The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout
the central nervous system that is a promising target for the treatment of various disorders …

Glucose is the mandatory fuel for the brain, yet the relative contribution of glucose and
lactate for neuronal energy metabolism is unclear. We found that increased lactate, but not …

Information processing imposes urgent metabolic demands on neurons, which have
negligible energy stores and restricted access to fuel. Here, we discuss metabolic …

Neural computational power is determined by neuroenergetics, but how and which energy
substrates are allocated to various forms of memory engram is unclear. To solve this …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …