Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes
spanning a wide range of biological functions,,,,–. The alterations in the human brain …

Recent developments in stem cell biology have enabled the study of cell fate decisions in
early human development that are impossible to study in vivo. However, understanding how …

Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in
response to cytokines. However, the cytokine responses in memory T cells remain largely …

Single-cell omics approaches provide high-resolution data on cellular phenotypes,
developmental dynamics and communication networks in diverse tissues and conditions …

Multiplexed single-cell RNA-seq analysis of multiple samples using pooling is a promising
experimental design, offering increased throughput while allowing to overcome batch …

Rapid cost drops and advancements in next-generation sequencing have made profiling of
cells at individual level a conventional practice in scientific laboratories worldwide. Single …

Over the past decade, genomic analyses of single cells—the fundamental units of life—have
become possible. Single-cell DNA sequencing has shed light on biological questions that …

Inter-patient variability and the similarity of healthy and leukemic stem cells (LSCs) have
impeded the characterization of LSCs in acute myeloid leukemia (AML) and their …