Comprehensive approaches to preclinical evaluation of monoclonal antibodies and their next-generation derivatives

S Singh, K Kachhawaha, SK Singh - Biochemical Pharmacology, 2024 - Elsevier
Biotherapeutics hold great promise for the treatment of severe diseases and offer innovative
possibilities for new treatments that target previously unaddressed medical needs. Despite …

An analysis of trends in the use of animal and non-animal methods in biomedical research and toxicology publications

K Taylor, S Modi, J Bailey - Frontiers in Lab on a Chip Technologies, 2024 - frontiersin.org
Introduction There have been relatively few attempts to quantitatively assess if, and in which
areas, the use of non-animal methods (NAMs) is increasing in biomedical research and …

The role of 'big data'and 'in silico'New Approach Methodologies (NAMs) in ending animal use–A commentary on progress

RN Ram, D Gadaleta, TEH Allen - Computational Toxicology, 2022 - Elsevier
In silico (computational) methods continue to evolve as part of a robust 21st century public
health strategy in risk assessment, relevant to all sectors of chemical safety including …

In Silico Trial Approach for Biomedical Products: A Regulatory Perspective

J Jose, B Mathew, DGT Parambi - Combinatorial Chemistry & …, 2022 - ingentaconnect.com
The modern pharmaceutical industry is transitioning from traditional methods to advanced
technologies like artificial intelligence. In the current scenario, continuous efforts are being …

Trends in the use of animals and non-animal methods over the last 20 years

K Taylor - ALTEX-Alternatives to animal experimentation, 2024 - altex.org
Despite the importance of the animal testing issue, there has been little presentation in the
scientific literature of the trends in animal use. This is crucial to resolve, particularly if we are …

Attitudes in China, Japan, and the Netherlands toward the use of animals in medical research

B Su, C Zhang, P Martens - Anthrozoös, 2022 - Taylor & Francis
The use of animals in medical research raises ethical challenges. In light of this moral issue,
this study sought to investigate and compare people's attitudes toward the use of ten animal …

The continued importance of animals in biomedical research

MCJ Chang, FB Grieder - Lab Animal, 2024 - nature.com
In the rapidly evolving field of biomedical research, the role of animal models has long been
a topic of scientific and ethical debate. However, despite advancements in alternative …

[PDF][PDF] In silico models for skin permeability prediction–Alternative ways to replace animal testing

QX Ling - pure.hud.ac.uk
Skin permeation plays an important role in drug administration for transdermal and topical
products in the pharmaceutical industry. To develop in silico models for skin permeability …

IN-SILICO EVALUATION OF BIOACTIVITY OF PHYCOCYANIN FROM RED ALGAE

R Sultana - 2022 - dspace.cvasu.ac.bd
Phycocyanin (PC) is a neutraceutical compound with biological action which is extracted
and purified from seaweeds. It is found in red algae, blue-green algae and different …

IN SILICO EVALUATION OF BIOACTIVE PEPTIDES FROM PYROPIA ORBICULARIS

MDI ISLAM - 2022 - dspace.cvasu.ac.bd
ome of the proteins in pyropia orbiculars could serve as starting points for creating bioactive
peptides. Peptides as a structural component of bioactive proteins In this virtual experiment …