Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …

PKC (protein kinase C) has been in the limelight since the discovery three decades ago that
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …

Rationale: Both fusion and fission contribute to mitochondrial quality control. How
unopposed fusion affects survival of cardiomyocytes and left ventricular function in the heart …

Rationale: NADPH oxidases are a major source of superoxide (O2−) in the cardiovascular
system. The function of Nox4, a member of the Nox family of NADPH oxidases, in the heart is …

Background—ST2 is an interleukin (IL)-1 receptor family member with membrane-bound
(ST2L) and soluble (sST2) isoforms, and sST2 is a biomarker for poor outcome in patients …

Rationale: NAD+ acts not only as a cofactor for cellular respiration but also as a substrate for
NAD+-dependent enzymes, such as Sirt1. The cellular NAD+ synthesis is regulated by both …

Activation of mammalian sterile 20–like kinase 1 (Mst1) by genotoxic compounds is known
to stimulate apoptosis in some cell types. The importance of Mst1 in cell death caused by …

PKCδ (protein kinase Cδ) is a serine/threonine kinase that plays a key role in growth
regulation and tissue remodelling. Traditional models of PKC activation have focused on …

Rationale: In Drosophila, the Hippo signaling pathway negatively regulates organ size by
suppressing cell proliferation and survival through the inhibition of Yorkie, a transcriptional …

Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of
increased basal oxidative stress. Since this state of oxidative stress makes cancer cells …