Oxidative stress in human pathology and aging: molecular mechanisms and perspectives

YA Hajam, R Rani, SY Ganie, TA Sheikh, D Javaid… - Cells, 2022 - mdpi.com
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

[HTML][HTML] Cellular Red-Ox system in health and disease: The latest update

AB Jena, RR Samal, NK Bhol, AK Duttaroy - Biomedicine & …, 2023 - Elsevier
Cells are continually exposed to reactive oxygen species (ROS) generated during cellular
metabolism. Apoptosis, necrosis, and autophagy are biological processes involving a …

Oxidative stress in ageing and chronic degenerative pathologies: molecular mechanisms involved in counteracting oxidative stress and chronic inflammation

TS Leyane, SW Jere, NN Houreld - International journal of molecular …, 2022 - mdpi.com
Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Oxidative stress mitigation by antioxidants-an overview on their chemistry and influences on health status

AM Pisoschi, A Pop, F Iordache, L Stanca… - European Journal of …, 2021 - Elsevier
The present review paper focuses on the chemistry of oxidative stress mitigation by
antioxidants. Oxidative stress is understood as a lack of balance between the pro-oxidant …

[HTML][HTML] NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's …

MW Park, HW Cha, J Kim, JH Kim, H Yang, S Yoon… - Redox biology, 2021 - Elsevier
Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD).
Mitochondrial dysfunction is linked to oxidative stress and reactive oxygen species (ROS) in …

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease

A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances

W Wang, F Zhao, X Ma, G Perry, X Zhu - Molecular neurodegeneration, 2020 - Springer
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Oxidative stress: a key modulator in neurodegenerative diseases

A Singh, R Kukreti, L Saso, S Kukreti - Molecules, 2019 - mdpi.com
Oxidative stress is proposed as a regulatory element in ageing and various neurological
disorders. The excess of oxidants causes a reduction of antioxidants, which in turn produce …