Diabetic nephropathy, a kidney complication arising from diabetes, is the leading cause of
death in diabetic patients. Unabated, the growing epidemic of diabetes is increasing …

Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in
regulating inflammation. Inflammation is associated with accumulation and turnover of HA …

BACKGROUND: Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant,
is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G …

Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and
progressive renal injury. Background Macrophage-mediated renal injury has been …

Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

Renal cells are a rich source of transforming growth factor (TGF)-β, and they serve as targets
for its actions. Our hypothesis that activation of the TGF-β system in the kidney is implicated …

Molecular mechanisms of diabetic renal hypertrophy. Altered growth of renal cells is one of
the early abnormalities detected after the onset of diabetes. Cell culture studies whereby …

Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human
diabetic nephropathy. Background We previously described that monocyte chemoattractant …

At present, diabetic kidney disease affects about 15–25% of type 1 and 30–40% of type 2
diabetic patients. Several decades of extensive research has elucidated various pathways to …

The PDGF system, comprising four isoforms (PDGF-A,-B,-C, and-D) and two receptor chains
(PDGFR-α and-β), plays important roles in wound healing, atherosclerosis, fibrosis, and …