At a first glance, ribosome biogenesis and chromatin remodeling are quite different
processes, but they share a common problem involving interactions between charged …

Chromatin is the complex of eukaryotic DNA and proteins required for the efficient
compaction of the nearly 2-meter-long human genome into a roughly 10-micron-diameter …

Ribosomes and protein synthesis have been reported to be altered in the cerebral cortex at
advanced stages of Alzheimer's disease (AD). Modifications in the hippocampus with …

Sperm chromatin remodeling after oocyte entry is the essential step that initiates
embryogenesis. This reaction involves the removal of sperm-specific basic proteins and …

Adipose tissue is regarded as a true endocrine organ that releases adipokines to regulate
distant targets. Besides the well-studied secretory adipokines, the adipokines carried by …

Linker histone H1 plays an essential role in chromatin organization. Proper deposition of
linker histone H1 as well as its removal is essential for chromatin dynamics and function …

The expression of subunits of mitochondrial respiratory complexes and components of the
protein synthesis machinery from the nucleolus to the ribosome was analyzed in the …

The histone demethylase JMJD2A/KDM4A facilitates prostate cancer development, yet how
JMJD2A function is regulated has remained elusive. Here, we demonstrate that SET7/9 …

Abnormal regulation of RNA binding proteins (RBPs) plays an essential role in
tumorigenesis and progression, but their functions and mechanisms remain largely elusive …

Background Lung cancer is the leading cause of cancer-related deaths worldwide, and
despite recent advances in targeted therapies and immunotherapies, the clinical benefit …