The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of
ECM remodeling can lead to tumorigenesis and cancer development by providing favorable …

Perlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a
wide array of tissues where it regulates diverse cellular processes including bone formation …

Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …

Decorin is an extracellular matrix protein that belongs to the family of small leucine‐rich
proteoglycans. As a matrix protein, the first discovered role of decorin is participating in …

Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly
complex process. It is regulated in a finely-tuned manner by numerous molecules including …

Inflammation and autophagy have emerged as prominent issues in the context of
proteoglycan signaling. In particular, two small, leucine‐rich proteoglycans, biglycan and …

Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …

Decorin is a prototypical small leucine-rich proteoglycan that epitomizes the multifunctional
nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine …

The tumor microenvironment encompasses a complex cellular network that includes cancer-
associated fibroblasts, inflammatory cells, neo-vessels, and an extracellular matrix enriched …