Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

Since the discovery of the histamine H 3 receptor in 1983, tremendous advances in the
pharmacological aspects of H 3 receptor antagonists/inverse agonists have been …

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …

Neuropathic pain is more prevalent in women. However, females are under-represented in
animal experiments, and the mechanisms of sex differences remain inadequately …

A relationship appears to exist between dysfunction of brain histamine (HA) and various
neuropsychiatric brain disorders. The possible involvement of brain HA in neuropathology …

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a painful condition,
experienced by patients undergoing chemotherapy with some specific drugs, such as …

Patients with chronic pain often report being sensitive to pain at night before falling asleep, a
time when the synchronization of cortical activity is initiated. However, how cortical activity …

Neuropathic pain (NP) remains an untreatable disease due to the complex pathophysiology
that involves the whole pain neuraxis including the forebrain. Sensory dysfunctions such as …

Oxaliplatin is an essential drug in the chemotherapy of colorectal, gastric, and pancreatic
cancers, but it frequently causes peripheral neuropathy as a dose-limiting factor. So far …

Introduction: Since years, ligands blocking histamine H3 receptor (H3R) activity
(antagonists/inverse agonists) are interesting targets in the search for new cures for CNS …