Renin‐angiotensin system revisited

F Fyhrquist, O Saijonmaa - Journal of internal medicine, 2008 - Wiley Online Library
New components and functions of the renin‐angiotensin system (RAS) are still being
unravelled. The classical RAS as it looked in the middle 1970s consisted of circulating renin …

A new perspective on the renin-angiotensin system

A Martyniak, PJ Tomasik - Diagnostics, 2022 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of death in the world. Hypertension is a
serious medical problem not only in adults but also in children and adolescents. The renin …

Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases

SM Nwia, APO Leite, XC Li, JL Zhuo - Frontiers in Cardiovascular …, 2023 - frontiersin.org
Cardiovascular disease is a pathology that exhibits well-researched biological sex
differences, making it possible for physicians to tailor preventative and therapeutic …

Angiotensin III: a physiological relevant peptide of the renin angiotensin system

VG Yugandhar, MA Clark - Peptides, 2013 - Elsevier
The renin angiotensin system (RAS) is a peptide hormone system that plays an important
role in the pathophysiology of various diseases, including congestive heart failure …

Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor

J Yatabe, M Yoneda, MS Yatabe, T Watanabe… - …, 2011 - academic.oup.com
Abstract Angiotensin II (Ang II) and Ang III stimulate aldosterone secretion by adrenal
glomerulosa, but the angiotensin receptor subtypes involved and the effects of Ang IV and …

The impact of angiotensin-converting enzyme-2/angiotensin 1-7 Axis in establishing severe COVID-19 consequences

MA Maranduca, DM Tanase, CT Cozma, N Dima… - Pharmaceutics, 2022 - mdpi.com
The COVID-19 pandemic has put a tremendous stress on the medical community over the
last two years. Managing the infection proved a lot more difficult after several research …

Blood pressure and renal hemodynamic effects of angiotensin fragments

R Yang, I Smolders, AG Dupont - Hypertension Research, 2011 - nature.com
Angiotensin (Ang) II, the main effector peptide of the renin–Ang system, increases arterial
blood pressure through Ang II type 1A (AT 1a) receptor-dependent arterial vasoconstriction …

Prolylcarboxypeptidase: a cardioprotective enzyme

J Mallela, J Yang, Z Shariat-Madar - … journal of biochemistry & cell biology, 2009 - Elsevier
Prolylcarboxypeptidase (PRCP) is involved in regulating the blood flow through active
tissues in order to preserve the internal environment. The expression of PRCP in tissues is …

Impaired angiotensin II signaling in septic shock

A Picod, B Garcia, D Van Lier, P Pickkers… - Annals of Intensive …, 2024 - Springer
Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone
system in critically ill patients. Emerging data suggest that this vital homeostatic system …

Dose-dependent bidirectional effect of angiotensin IV on abdominal aortic aneurysm via variable angiotensin receptor stimulation

J Kong, K Zhang, X Meng, Y Zhang, C Zhang - Hypertension, 2015 - Am Heart Assoc
Angiotensin IV (Ang IV), as an effector peptide of the rennin–angiotensin system, possesses
many biological properties yet not completely known. In this study, we aimed to investigate …