Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-
dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron …

Ferroptosis is a newly discovered type of cell death that differs from traditional apoptosis and
necrosis and results from iron‐dependent lipid peroxide accumulation. Ferroptotic cell death …

Mitochondria are the key source of ATP that fuels cellular functions, and they are also central
in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been …

Therapeutics that discriminate between the genetic makeup of normal cells and tumour cells
are valuable for treating and understanding cancer. Small molecules with oncogene …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an
accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Oxidative stress is a major cause of defective sperm function in cases of male infertility. Such
stress is known to be associated with high levels of superoxide production by the sperm …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that
is overexpressed in apoptosis and in several human chronic pathologies. Here, we report …

Purpose: Cisplatin adducts to nuclear DNA (nDNA) are felt to be the molecular lesions that
trigger apoptosis, but the mechanism linking nDNA adduct formation and cell death is …