Metabolic regulation of gene expression through histone acylations
Eight types of short-chain Lys acylations have recently been identified on histones:
propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation …
propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation …
The growing landscape of lysine acetylation links metabolism and cell signalling
Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes
Mammalian SWI/SNF (mSWI/SNF) adenosine triphosphate–dependent chromatin
remodelers modulate genomic architecture and gene expression and are frequently mutated …
remodelers modulate genomic architecture and gene expression and are frequently mutated …
Histone methylation: a dynamic mark in health, disease and inheritance
EL Greer, Y Shi - Nature Reviews Genetics, 2012 - nature.com
Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription
CE Barnes, DM English, SM Cowley - Essays in biochemistry, 2019 - portlandpress.com
Packaging the long and fragile genomes of eukaryotic species into nucleosomes is all well
and good, but how do cells gain access to the DNA again after it has been bundled away …
and good, but how do cells gain access to the DNA again after it has been bundled away …
Perceiving the epigenetic landscape through histone readers
CA Musselman, ME Lalonde, J Côté… - Nature structural & …, 2012 - nature.com
Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
Understanding the function of mammalian sirtuins and protein lysine acylation
Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …
Genetics of congenital heart disease: the glass half empty
AC Fahed, BD Gelb, JG Seidman… - Circulation research, 2013 - Am Heart Assoc
Congenital heart disease (CHD) is the most common congenital anomaly in newborn
babies. Cardiac malformations have been produced in multiple experimental animal …
babies. Cardiac malformations have been produced in multiple experimental animal …
In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis
D Lara-Astiaso, A Goñi-Salaverri, J Mendieta-Esteban… - Nature …, 2023 - nature.com
Cellular differentiation requires extensive alterations in chromatin structure and function,
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …
which is elicited by the coordinated action of chromatin and transcription factors. By contrast …
Drug discovery targeting bromodomain-containing protein 4
BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …
that localizes to DNA via binding to acetylated histones and controls the expression of …