Viral membrane fusion: a dance between proteins and lipids
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …
members of high concern for global human health. All enveloped viruses have a dedicated …
Mass spectrometry-based structural virology
Here we review recent developments in mass spectrometry that have enabled its growing
contribution to the field of structural virology. Evidently, there is a strong renewed general …
contribution to the field of structural virology. Evidently, there is a strong renewed general …
Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein
Vesicular stomatitis virus (VSV) is an oncolytic rhabdovirus and its glycoprotein G is widely
used to pseudotype other viruses for gene therapy. Low-density lipoprotein receptor (LDL-R) …
used to pseudotype other viruses for gene therapy. Low-density lipoprotein receptor (LDL-R) …
Different functional states of fusion protein gB revealed on human cytomegalovirus by cryo electron tomography with Volta phase plate
Human cytomegalovirus (HCMV) enters host by glycoprotein B (gB)-mediated membrane
fusion upon receptor-binding to gH/gL-related complexes, causing devastating diseases …
fusion upon receptor-binding to gH/gL-related complexes, causing devastating diseases …
Structural analysis of rabies virus glycoprotein reveals pH-dependent conformational changes and interactions with a neutralizing antibody
F Yang, S Lin, F Ye, J Yang, J Qi, Z Chen, X Lin… - Cell host & …, 2020 - cell.com
Rabies virus (RABV), the etiological agent for the lethal disease of rabies, is a deadly
zoonotic pathogen. The RABV glycoprotein (RABV-G) is a key factor mediating virus entry …
zoonotic pathogen. The RABV glycoprotein (RABV-G) is a key factor mediating virus entry …
The prefusion structure of herpes simplex virus glycoprotein B
B Vollmer, V Pražák, D Vasishtan, EE Jefferys… - Science …, 2020 - science.org
Cell entry of enveloped viruses requires specialized viral proteins that mediate fusion with
the host membrane by substantial structural rearrangements from a metastable pre-to a …
the host membrane by substantial structural rearrangements from a metastable pre-to a …
Structural transition of GP64 triggered by a pH-sensitive multi-histidine switch
J Guo, S Li, L Bai, H Zhao, W Shang, Z Zhong… - Nature …, 2024 - nature.com
The fusion of viruses with cellular membranes is a critical step in the life cycle of enveloped
viruses. This process is facilitated by viral fusion proteins, many of which are …
viruses. This process is facilitated by viral fusion proteins, many of which are …
Visualizing intermediate stages of viral membrane fusion by cryo-electron tomography
SM Kephart, N Hom, KK Lee - Trends in Biochemical Sciences, 2024 - cell.com
Protein-mediated membrane fusion is the dynamic process where specialized protein
machinery undergoes dramatic conformational changes that drive two membrane bilayers …
machinery undergoes dramatic conformational changes that drive two membrane bilayers …
Structure of trimeric pre-fusion rabies virus glycoprotein in complex with two protective antibodies
WM Ng, S Fedosyuk, S English, G Augusto, A Berg… - Cell host & …, 2022 - cell.com
Rabies virus (RABV) causes lethal encephalitis and is responsible for approximately 60,000
deaths per year. As the sole virion-surface protein, the rabies virus glycoprotein (RABV-G) …
deaths per year. As the sole virion-surface protein, the rabies virus glycoprotein (RABV-G) …
Structural and cellular biology of rhabdovirus entry
L Belot, A Albertini, Y Gaudin - Advances in virus research, 2019 - Elsevier
Rhabdoviruses are enveloped viruses with a negative-sense single strand RNA genome
and are widespread among a great variety of organisms. In their membrane, they have a …
and are widespread among a great variety of organisms. In their membrane, they have a …