Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

RA Nixon, DC Rubinsztein - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

Fluorescent probes for the detection of disease-associated biomarkers

WT Dou, HH Han, AC Sedgwick, GB Zhu, Y Zang… - Science Bulletin, 2022 - Elsevier
Fluorescent probes have emerged as indispensable chemical tools to the field of chemical
biology and medicine. The ability to detect intracellular species and monitor physiological …

Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment

Y Esmaeili, Z Yarjanli, F Pakniya, E Bidram… - Journal of Controlled …, 2022 - Elsevier
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …

Discerning the chemistry in individual organelles with small‐molecule fluorescent probes

W Xu, Z Zeng, JH Jiang, YT Chang… - Angewandte Chemie …, 2016 - Wiley Online Library
Principle has it that even the most advanced super‐resolution microscope would be futile in
providing biological insight into subcellular matrices without well‐designed fluorescent …

Life, death, and autophagy in cancer: NF-κB turns up everywhere

D Verzella, A Pescatore, D Capece, D Vecchiotti… - Cell death & …, 2020 - nature.com
Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key
regulator of cell survival and aberrant NF-κB signaling has been involved in the …

[HTML][HTML] Functions and dysfunctions of nitric oxide in brain

P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

Oxidative stress and autophagy: the clash between damage and metabolic needs

G Filomeni, D De Zio, F Cecconi - Cell Death & Differentiation, 2015 - nature.com
Autophagy is a catabolic process aimed at recycling cellular components and damaged
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …

Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis

M Pavel, M Renna, SJ Park, FM Menzies… - Nature …, 2018 - nature.com
Contact inhibition enables noncancerous cells to cease proliferation and growth when they
contact each other. This characteristic is lost when cells undergo malignant transformation …

Nitric oxide synthase in innate and adaptive immunity: an update

C Bogdan - Trends in immunology, 2015 - cell.com
Thirty years after the discovery of its production by activated macrophages, our appreciation
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …

Autophagy induction as a therapeutic strategy for neurodegenerative diseases

A Djajadikerta, S Keshri, M Pavel, R Prestil… - Journal of molecular …, 2020 - Elsevier
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …