Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
RA Nixon, DC Rubinsztein - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
Fluorescent probes for the detection of disease-associated biomarkers
Fluorescent probes have emerged as indispensable chemical tools to the field of chemical
biology and medicine. The ability to detect intracellular species and monitor physiological …
biology and medicine. The ability to detect intracellular species and monitor physiological …
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …
molecular mechanisms involved in this process, such as autophagy, may contribute to …
Discerning the chemistry in individual organelles with small‐molecule fluorescent probes
Principle has it that even the most advanced super‐resolution microscope would be futile in
providing biological insight into subcellular matrices without well‐designed fluorescent …
providing biological insight into subcellular matrices without well‐designed fluorescent …
Life, death, and autophagy in cancer: NF-κB turns up everywhere
D Verzella, A Pescatore, D Capece, D Vecchiotti… - Cell death & …, 2020 - nature.com
Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key
regulator of cell survival and aberrant NF-κB signaling has been involved in the …
regulator of cell survival and aberrant NF-κB signaling has been involved in the …
[HTML][HTML] Functions and dysfunctions of nitric oxide in brain
P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …
flow and also has important roles in intracellular signaling in neurons from the regulation of …
Oxidative stress and autophagy: the clash between damage and metabolic needs
G Filomeni, D De Zio, F Cecconi - Cell Death & Differentiation, 2015 - nature.com
Autophagy is a catabolic process aimed at recycling cellular components and damaged
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …
Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
M Pavel, M Renna, SJ Park, FM Menzies… - Nature …, 2018 - nature.com
Contact inhibition enables noncancerous cells to cease proliferation and growth when they
contact each other. This characteristic is lost when cells undergo malignant transformation …
contact each other. This characteristic is lost when cells undergo malignant transformation …
Nitric oxide synthase in innate and adaptive immunity: an update
C Bogdan - Trends in immunology, 2015 - cell.com
Thirty years after the discovery of its production by activated macrophages, our appreciation
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …
Autophagy induction as a therapeutic strategy for neurodegenerative diseases
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …
contents to lysosomes for degradation. Genetic studies have revealed extensive links …