The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited

DH Anderson, MJ Radeke, NB Gallo, EA Chapin… - Progress in retinal and …, 2010 - Elsevier
During the past ten years, dramatic advances have been made in unraveling the biological
bases of age-related macular degeneration (AMD), the most common cause of irreversible …

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related …

GS Hageman, PJ Luthert, NHV Chong… - Progress in retinal and …, 2001 - Elsevier
Age-related macular degeneration (AMD) is a blinding disease that afflicts millions of adults
in the Western world. Although it has been proposed that a threshold event occurs during …

Complement factor H polymorphism in age-related macular degeneration

RJ Klein, C Zeiss, EY Chew, JY Tsai, RS Sackler… - Science, 2005 - science.org
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We
report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated …

Complement factor H polymorphism and age-related macular degeneration

AO Edwards, R Ritter III, KJ Abel, A Manning… - Science, 2005 - science.org
Age-related macular degeneration (AMD) is a common, late-onset, and complex trait with
multiple risk factors. Concentrating on a region harboring a locus for AMD on 1q25-31, the …

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

GS Hageman, DH Anderson… - Proceedings of the …, 2005 - National Acad Sciences
Age-related macular degeneration (AMD) is the most frequent cause of irreversible
blindness in the elderly in developed countries. Our previous studies implicated activation of …

A role for local inflammation in the formation of drusen in the aging eye

DH Anderson, RF Mullins, GS Hageman… - American journal of …, 2002 - Elsevier
PURPOSE: The accumulation of numerous or confluent drusen, especially in the macula, is
a significant risk factor for the development of age-related macular degeneration (AMD) …

Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts

KM Gehrs, DH Anderson, LV Johnson… - Annals of …, 2006 - Taylor & Francis
Today, the average life expectancy in developed nations is over 80 years and climbing. And
yet, the quality of life during those additional years is often significantly diminished by the …

Complement C3 variant and the risk of age-related macular degeneration

JRW Yates, T Sepp, BK Matharu, JC Khan… - … England Journal of …, 2007 - Mass Medical Soc
Background Age-related macular degeneration is the most common cause of blindness in
Western populations. Susceptibility is influenced by age and by genetic and environmental …

Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study

Z Yehoshua, CA de Amorim Garcia Filho, RP Nunes… - Ophthalmology, 2014 - Elsevier
Purpose To evaluate the effect of eculizumab, a systemic inhibitor of complement
component (C5), on the growth of geographic atrophy (GA) in patients with age-related …

[HTML][HTML] The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment

MJ Geerlings, EK de Jong, AI den Hollander - Molecular immunology, 2017 - Elsevier
Age-related macular degeneration (AMD) is a progressive retinal disease and the major
cause of irreversible vision loss in the elderly. Numerous studies have found both common …