Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications

SM Francque, D Van Der Graaff, WJ Kwanten - Journal of hepatology, 2016 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most frequent chronic liver
diseases in the Western society and its prevalence is likely to rise even further. An …

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

R Wang - Physiological reviews, 2012 - journals.physiology.org
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

[HTML][HTML] Hydrogen sulfide chemical biology: pathophysiological roles and detection

GK Kolluru, X Shen, SC Bir, CG Kevil - Nitric oxide, 2013 - Elsevier
Hydrogen sulfide (H 2 S) is the most recent endogenous gasotransmitter that has been
reported to serve many physiological and pathological functions in different tissues. Studies …

The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair

B Vollmar, MD Menger - Physiological reviews, 2009 - journals.physiology.org
The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Synthesis and Biological Effects of Hydrogen Sulfide (H2S): Development of H2S-Releasing Drugs as Pharmaceuticals

G Caliendo, G Cirino, V Santagada… - Journal of medicinal …, 2010 - ACS Publications
Gaseous transmitters are a growing family of regulatory molecules involved in multilevel
regulation of physiological and pathological functions in mammalian tissues. 1 Hydrogen …

Homocysteine to hydrogen sulfide or hypertension

U Sen, PK Mishra, N Tyagi, SC Tyagi - Cell biochemistry and biophysics, 2010 - Springer
Hyperhomocysteinemia, an increased level of plasma homocysteine, is an independent risk
factor for the development of premature arterial fibrosis with peripheral and cerebro …

Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway

M Li, C Xu, J Shi, J Ding, X Wan, D Chen, J Gao, C Li… - Gut, 2018 - gut.bmj.com
Objective Accumulation of free fatty acids (FFAs) in hepatocytes induces lipotoxicity, leading
to non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the underlying …

The role of homocysteine‐lowering B‐vitamins in the primary prevention of cardiovascular disease

B Debreceni, L Debreceni - Cardiovascular therapeutics, 2014 - Wiley Online Library
Cardiovascular disease (CVD) is the leading cause of mortality in the Western world. The
effort of research should aim at the primary prevention of CVD. Alongside statin therapy …

[HTML][HTML] Non-alcoholic fatty liver disease and cardiovascular comorbidities: pathophysiological links, diagnosis, and therapeutic management

A Jichitu, S Bungau, AMA Stanescu, CM Vesa… - Diagnostics, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) has a growing prevalence in recent years. Its
association with cardiovascular disease has been intensively studied, and certain …

[HTML][HTML] Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats

G Tan, S Pan, J Li, X Dong, K Kang, M Zhao, X Jiang… - PloS one, 2011 - journals.plos.org
Background Hydrogen sulfide (H2S) displays vasodilative, anti-oxidative, anti-inflammatory
and cytoprotective activities. Impaired production of H2S contributes to the increased …