Background: Despite the development of new therapies for leishmaniasis, among the 200
countries or territories reporting to the WHO, 87 were identified as endemic for Tegumentary …

Modified flavonoids of the sub-group of pterocarpans, 5-carba-pterocarpans, 5-
carbapterocarpens, 1-carba-isoflavanones, coumestans, and aurones were synthesized and …

The electrochemistry of a redox‐based bioactive pterocarpanquinone, designated as LQB‐
118, and its precursor chromenquinone (CQ) was investigated in protic and aprotic media …

Glioblastoma (GBM) is the most frequent malignant brain tumor. It represents the most
aggressive astrocytoma with an overall survival of 14 months. Despite improvements in …

N-alkylated and O-alkylated anthraquinone derivatives with structures analogous to
mitoxantrone were synthesized, characterized, and evaluated for their cytotoxic properties …

The racemic pterocarpanquinone LQB‐118 is active, in mice and hamsters, against
tegumentary and visceral leishmaniasis. This compound also presents antiinflammatory and …

Background/Aim: Prostate cancer (PCa) is one of the most common malignancies in adult
men. LQB-118 is a pterocarpanquinone with antitumor activity toward prostate cancer cells …

LQB 118, a hydride molecule, has been described as an antineoplastic and antiparasitic
drug. Recently, LQB118 was also shown to display anti-inflammatory properties using an …

In an attempt to find anticancer agents that could overcome multidrug resistance (MDR), two
new classes of modified isoflavonoids were designed and synthesized, and their …